PEGylation and Activated PEGs

NOF provides 2-branched Activated PEGs, as illustrated below. Both the molecular weights of the respective PEG chains and the linker moieties leading to the functional groups are adjustable. These are available with amino, aldehyde, maleimide, carbonate and carboxylate activated esters as the terminal functional groups.
Furthermore, NOF has also developed newer types of Branched Activated PEGs, such as 3-branched and 4-branched derivatives. Although aqueous solutions of higher-molecular PEG derivatives tend to show increased viscosity, use of higher-branched Activated PEGs, such as 3-branched and 4-branched derivatives, is useful to reduce the viscosity of the relevant aqueous solutions, even without any change of the molecular weights.