PEGylation and Activated PEGs

　Advantage of PEGylation

PEGylation technology is now widely used for the modification of proteins, peptides, antibody fragments, oligonucleotides and the like for use as drugs. Among the advantages of PEGylation technology are the following:

• increased bioavailability,
• increased blood circulation of the drug,
• optimized pharmacokinetics,
• decreased immunogenicity, and
• decreased frequency of administration.

NOF offers a wide variety of high-quality activated PEGs for the production of PEGylated drugs from the research and development stages through to commercialization. The correct choice of activated PEG is important if the customer is to succeed in their drug-development efforts. NOF has been producing high-quality methoxypoly(ethylene glycol)s (mPEG) for the pharmaceutical field for more than 20 years. These products have a narrow polydispersity and a low diol content and they are available in a wide range of molecular weights from 2000 to 30,000. Our mPEGs have been used as key materials for the production of commercialized PEGylated drugs.

NOF supports customers' efforts to produce PEGylated drugs using our wide range of activated PEGs: please contact us for more details.

　PEGylation Service

1. Pure PEGylation
NOF offers our sophisticated Pure PEGylation Technology. Peptide and protein can be mono-PEGylated with NOF’s high-quality activated PEGs and novel branched PEGs. Customers, who wants to evaluate PEGylated their drug, can readily obtain the PEGylated drug from NOF. Then customers can evaluate PEGylated drug with both linear and branched PEGs at the same time and can know whether the PEGylated drug suitable technology for your drug. For more detail about Pure PEGylation, please feel free to contact us.